| # |
Ovr |
Player |
Pts |
Avg |
Yds |
Att |
TD |
Fum Lost |
Yds |
Rec |
TD |
Fum Lost |
Tgt |
Status |
Bye |
| 1. | 1. | Tomlinson, Ladainian SDC RB | 311.58 | 19.474 | 1474 | 315 | 15 | 0 | 475 | 60 | 3 | 0 | | Detroit Lions | 7 |
| 2. | 2. | Peterson, Adrian MIN RB (R) | 247.71 | 17.694 | 1341 | 238 | 12 | 6 | 268 | 19 | 1 | 6 | | Minnesota Vikings | 5 |
| 3. | 3. | Westbrook, Brian PHI RB | 287.45 | 19.163 | 1333 | 278 | 7 | 2 | 771 | 90 | 5 | 2 | | Detroit Lions | 5 |
| 4. | 4. | Parker, Willie PIT RB | 154.30 | 10.287 | 1317 | 321 | 2 | 6 | 166 | 23 | 0 | 6 | | Minnesota Vikings (I) | 6 |
| 5. | 5. | Lewis, Jamal CLE RB | 218.20 | 14.547 | 1304 | 298 | 9 | 4 | 248 | 30 | 2 | 4 | | Pittsburgh Steelers | 7 |
| 6. | 6. | Portis, Clinton WAS RB | 232.70 | 14.544 | 1262 | 325 | 11 | 10 | 389 | 47 | 0 | 10 | | Minnesota Vikings | 4 |
| 7. | 7. | James, Edgerrin ARI RB | 186.80 | 11.675 | 1232 | 324 | 7 | 0 | 196 | 25 | 0 | 0 | | Denver Broncos | 8 |
| 8. | 8. | McGahee, Willis BAL RB | 186.80 | 12.453 | 1207 | 294 | 7 | 6 | 231 | 43 | 1 | 6 | | Indianapolis Colts | 8 |
| 9. | 9. | Taylor, Fred JAC RB | 154.40 | 10.293 | 1202 | 223 | 5 | 2 | 62 | 9 | 0 | 2 | | New England Patriots | 4 |
| 10. | 10. | Jones, Thomas NYJ RB | 146.60 | 9.163 | 1119 | 310 | 1 | 0 | 217 | 28 | 1 | 0 | | Philadelphia Eagles | 10 |
| 11. | 11. | Lynch, Marshawn BUF RB (R) | 178.22 | 13.709 | 1115 | 280 | 7 | 2 | 184 | 18 | 0 | 2 | | New Orleans Saints | 6 |
| 12. | 12. | White, LenDale TEN RB | 158.80 | 9.925 | 1108 | 304 | 7 | 8 | 115 | 20 | 0 | 8 | | Oakland Raiders | 4 |
| 13. | 13. | Gore, Frank SFO RB | 186.80 | 12.453 | 1102 | 260 | 5 | 6 | 436 | 53 | 1 | 6 | | Philadelphia Eagles | 6 |
| 14. | 14. | Addai, Joseph IND RB | 236.60 | 15.773 | 1072 | 261 | 12 | 0 | 364 | 41 | 3 | 0 | | New Orleans Saints | 6 |
| 15. | 15. | Jacobs, Brandon NYG RB | 146.50 | 13.318 | 1011 | 200 | 4 | 8 | 174 | 23 | 2 | 8 | | Indianapolis Colts | 9 |
| 16. | 16. | Fargas, Justin OAK RB | 142.20 | 10.157 | 1009 | 222 | 4 | 2 | 188 | 23 | 0 | 2 | | Detroit Lions (I) | 5 |
| 17. | 17. | Jackson, Steven STL RB | 166.38 | 13.865 | 1002 | 237 | 5 | 4 | 271 | 38 | 1 | 4 | | New England Patriots | 9 |
| 18. | 18. | Barber, Marion DAL RB | 200.50 | 12.531 | 979 | 203 | 10 | 0 | 286 | 44 | 2 | 0 | | Houston Texans | 8 |
| 19. | 19. | Grant, Ryan GBP RB | 160.10 | 10.673 | 956 | 188 | 8 | 2 | 150 | 30 | 0 | 2 | | Philadelphia Eagles | 7 |
| 20. | 20. | Graham, Earnest TBB RB | 185.45 | 12.363 | 898 | 222 | 10 | 2 | 324 | 49 | 0 | 2 | | New England Patriots | 10 |
| 21. | 21. | Foster, De'shaun CAR RB | 123.40 | 7.713 | 881 | 247 | 3 | 8 | 173 | 24 | 1 | 8 | | New Orleans Saints | 7 |
| 22. | 22. | Taylor, Chester MIN RB | 146.50 | 10.464 | 844 | 157 | 7 | 8 | 281 | 29 | 0 | 8 | | Minnesota Vikings | 5 |
| 23. | 23. | Maroney, Laurence NEP RB | 133.10 | 10.238 | 835 | 185 | 6 | 0 | 116 | 4 | 0 | 0 | | New England Patriots | 10 |
| 24. | 24. | Dayne, Ron HOU RB | 124.70 | 9.592 | 773 | 194 | 6 | 0 | 114 | 17 | 0 | 0 | | New York Giants | 10 |
| 25. | 25. | Jones-Drew, Maurice JAC RB | 198.22 | 13.215 | 768 | 167 | 9 | 4 | 407 | 40 | 0 | 4 | | New York Giants | 4 |
| 26. | 26. | Watson, Kenny CIN RB | 154.60 | 9.663 | 763 | 178 | 7 | 4 | 373 | 52 | 0 | 4 | | Denver Broncos | 5 |
| 27. | 27. | Young, Selvin DEN RB (R) | 101.41 | 6.761 | 729 | 140 | 1 | 2 | 231 | 35 | 0 | 2 | | New England Patriots | 6 |
| 28. | 28. | Dunn, Warrick ATL RB | 116.60 | 7.288 | 718 | 228 | 4 | 4 | 238 | 37 | 0 | 4 | | Detroit Lions | 8 |
| 29. | 29. | Williams, DeAngelo CAR RB | 122.20 | 7.637 | 717 | 144 | 4 | 4 | 177 | 24 | 1 | 4 | | Philadelphia Eagles | 7 |
| 30. | 30. | Alexander, Shaun SEA RB | 109.20 | 8.400 | 716 | 207 | 4 | 0 | 76 | 14 | 1 | 0 | | Indianapolis Colts | 8 |
